Figure 2 from Testosterone Trajectories and Reference Ranges in a Large Longitudinal Sample of Male Adolescents | Semantic Scholar (2024)

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Results showed that the cumulative exposure to testosterone during adolescence moderated the relation between adult testosterone and both the mean fMRI response and functional connectivity and suggested that sensitivity to cues carried by the eyes might underlie the relationship between testosterone and brain response to faces, especially in the context of a potential threat.

This study elucidates a robust inverse correlation between serum TT concentration and apoB concentration, maintaining statistical significance even upon adjustment for confounding factors, and presents a promising avenue for addressing the prevention and treatment of low testosterone and CVD.

Many of these young male athletes had poor bone health at baseline, and most either lost or did not achieve the expected pubertal bone mineral accrual, although no other indication of REDs was observed, while performance improved during the study period.

The occurance of multiple prolactinomas in a patient with Kallmann syndrome suggests increased susceptibility and the relevance of the CASR gene variant in the authors' patient for the KS phenotype is unclear at present.

Some forms of functional hypogonadism in adolescents are highlighted and the clinical challenges to differentiate normal variants from pathological states are highlighted.

It was found that adolescent chimpanzees were more risk-seeking than adults, as in humans, however, chimpanzees showed no developmental change in intertemporal choice, unlike humans, although younger chimpanzees did exhibit elevated emotional reactivity to waiting compared to adults.

The findings of the present study suggest that growth-mediated changes in neuromuscular function lead to improvements in the efficiency of muscular activation and augmentations in motor unit recruitment strategies.

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Using data from a sample of 478 males from a longitudinal birth cohort, the calculations of three independent height-based markers of pubertal timing are described: Age at Peak Height Velocity (APHV), Height Difference in Standard Deviations (HDSDS), and Percent Achieved of Adult Stature (PAAS).

Results confirm that Tanner criteria reflect gonadal hormone concentrations, and clinician rating provides optimal assessment, and detailed insight about the strengths and limitations of different raters is provided, augmenting the scientific understanding of pubertal development.

The Avon Longitudinal Study of Parents and Children (ALSPAC) is a transgenerational prospective observational study investigating influences on health and development across the life course and is currently set up as a supported access resource.

Levels of testosterone were significantly lower in adolescents with prodromal symptoms as compared with non-clinical controls, and level of testosterone was significantly correlated with age and Tanner pubertal stage.

The findings of the present study highlight the need to consider multiple sources of individual variability in pubertal development and suggest different puberal challenges for boys and girls.

The testosterone-related increase of white-matter volume was stronger in male adolescents with the lower versus higher number of CAG repeats in the AR gene, with testosterone explaining, respectively, 26 and 8% of variance in the volume.

The data show that after a peak of DHT:T in infancy and a subsequent decrease in puberty, the ratio of both androgens remains practically without change from 20 years of age till old age.

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